Generating Digital Twins with Multiple Sclerosis Using Probabilistic Neural Networks

Multiple Sclerosis (MS) is a neurodegenerative disorder characterized by a complex set of clinical assessments. We use an unsupervised machine learning model called a Conditional Restricted Boltzmann Machine (CRBM) to learn the relationships between covariates commonly used to characterize subjects and their disease progression in MS clinical trials. A CRBM is capable of generating digital twins, which are simulated subjects having the same baseline data as actual subjects. Digital twins allow for subject-level statistical analyses of disease progression. The CRBM is trained using data from 2395 subjects enrolled in the placebo arms of clinical trials across the three primary subtypes of MS. We discuss how CRBMs are trained and show that digital twins generated by the model are statistically indistinguishable from their actual subject counterparts along a number of measures.

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Unlearn.AI named to the 2021 CB Insights AI 100 List of Most Innovative Artificial Intelligence Startups

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Welcoming Dr. Taylor to Unlearn.AI’s Board of Directors

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Unlearn Appoints AstraZeneca’s Chief Medical Officer Ann E. Taylor, M.D. to Board of Directors

Ann E. Taylor, M.D., Chief Medical Officer at AstraZeneca, has joined the Unlearn Board of Directors.
I’m honored to have such an inspirational and experienced leader like Dr. Taylor join our board.
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