White Papers

White Papers

Summary of the EMA March 2022 Draft Qualification Opinion for PROCOVA™

Learn more about the highlights, implications, and FAQs concerning the European Medicines Agency’s draft qualification opinion for our 3-step PROCOVA™ procedure.
White Papers

PROCOVA™ Handbook for the Target Trial Statistician

This handbook provides step-by-step guidance for the practical application of our PROCOVA™ procedure for Phase 2 or 3 TwinRCTs™.
White Papers

Using AI-based Prognostic Models to Design Efficient, Unbiased Clinical Trials

Statistical principles of clinical trials with Digital Twins
White Papers

Incorporating External Control Arms into Clinical Trials

Synthetic Controls and Digital Twins both increase power, but only Digital Twins are robust to known as well as unknown confounders.
White Papers

Applications of Digital Twins in Clinical Trials for Alzheimer’s Disease

How Digital Twins make it possible to design and run more efficient clinical trials with well-defined statistical properties.
White Papers

AI Driven Approaches to Trial Design Innovation

Enabling Faster, More Efficient Trials with Digital Twins