Driving clarity in clinical development

Every clinical trial is a chain of high-stakes decisions made by experts working across fragmented data, tools, and institutional memory. Unlearn integrates the evidence, modeling, and reasoning behind those decisions, so trial teams can commit with confidence, and so each decision builds on the last.

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Real-world Results

Control Arm Size Reduction*

Enrollment Time Saved (months)*

*Approximate values

Accelerating Clinical Development in Alzheimer’s Disease

We work in neuroscience, immunology, metabolic disease, and more.

View AbbVie Case Study

Solutions

The scientific intelligence layer for clinical development

Every trial is a chain of key decisions. We help you make each one more confidently.

Plan, monitor, analyze — one connected platform organized around the key decisions that shape every clinical trial.

Plan

Trial Planning and Simulations

Bring together the critical components for early planning and design — where decisions are iterative and rationale must stay defensible across review cycles. Teams work from a shared source of truth, reducing rework and accelerating alignment.

20%

Sample size reduction achieved

28%

Potential with Bayesian + twins

$250K

Per patient program savings

20%

Study design locked at 20% reduction

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Continuously search, structure, and summarize relevant literature and regulatory precedent from sources like PubMed, ClinicalTrials.gov, and drugs@FDA — all in one place. Eliminate scattered searches and align on precedent in days, not weeks.

Explore harmonized clinical trial and real-world datasets to validate clinical and statistical assumptions. Assess population characteristics, endpoint behavior, and benchmarks.

Build and compare trial-design scenarios to evaluate endpoints, inclusion/exclusion criteria, sample size, and constraints. Every scenario is reproducible, and linked to underlying evidence — supporting informed design trade-offs before protocol finalization.

Monitor

Advanced Trial Monitoring

Turn blinded signals into curated insights that support trial decision-making and keep execution on track.

PROOF POINT

Validated retrospectively in AD — In a reanalysis of the ADCS DHA Phase 3 trial (402 patients, 51 sites), Advanced Trial Monitoring flagged ADAS-Cog anomalies ~2 months into enrollment — surfacing coding errors ~7 months before the formal DSMB review.

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Analyze

Trial Analyses with Digital Twins

AI-generated digital twins forecast each participant’s control outcomes at every future time point — the powering technology for more rigorous analysis.

33%

Control-arm reduction, Ph3 Bapineuzumab

50%

Chance of observing a treatment effect

PROOF POINT

Digital twins boosted power from 80% to 90% on ADAS-Cog11 at 18 months using PROCOVA.

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Trusted by leading sponsors

“Working with Unlearn to mine their extensive, well-curated database through the use of the ALS DTG will enable us to explore smarter designs and make confident and informed decisions as we plan our Phase 1/2 trial. Ultimately, these insights can help us to move faster for people living with ALS who are waiting for new treatment options."

Eric Green, M.D., Ph.D., co-founder and CEO of Trace Neuroscience

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“The ecosystem at the moment doesn’t sustain the way we’ve been doing it traditionally. And (Unlearn) is at the leading edge of this thinking.”

Kasper Roet, founder and CEO of QurAlis

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"The collaboration with Unlearn and the resulting data further increases our confidence in our pioneering approach towards achieving symptomatic relief and disease modification in Alzheimer’s. This will support our efforts to advance an optimized second-generation therapy. Digital twins offer a new lens for interpreting biomarker trends over time—especially in early-stage trials where every data point matters."

Gerard Griffioen, Ph.D., CSO of remynd

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Partnerships

Collaborating with leaders to move the industry forward.

Explore how leading biopharma companies are applying Unlearn’s AI-powered solutions in active studies today to reach clinical milestones faster.

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July 9, 26