Boosting Clinical Trial Power in Parkinson's Disease with AI-Generated Digital Twins

Compared to a study originally powered at 80%, at one year, we can boost power up to 87% for MDS-UPDRS Total Score or 88% for MDS-UPDRS Motor Subscore without enrolling additional participants. This approach strengthens the reliability of trial outcomes and supports more confident decision-making, highlighting just one of the many applications of digital twins in clinical development.